◀ Back to INS

INS — PKN2

Text-mined interactions from Literome

Dong et al., Proc Natl Acad Sci U S A 2000 : Phosphorylation of protein kinase N by phosphoinositide dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton
Standaert et al., J Biol Chem 1998 : Comparative effects of GTPgammaS and insulin on the activation of Rho, phosphatidylinositol 3-kinase, and protein kinase N in rat adipocytes ... Whereas insulin activated both PKN and PKC-zeta, GTPgammaS activated PKN but not PKC-zeta ... Our findings suggest that ( a ) GTPgammaS and insulin activate Rho, PI 3-kinase, and PKN , albeit by different mechanisms ; ( b ) each of these signaling substances appears to be required for, and may contribute to, increases in glucose transport ; and ( c ) PKC-zeta may contribute to increases in glucose transport during insulin, but not GTPgammaS, action