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CCND1 — PRKCA
Text-mined interactions from Literome
Soh et al., J Biol Chem 2003
:
Transient transfection studies with a series of 5'-deleted cyclin D1 promoter constructs showed that the proximal 964-base region, which contains AP-1, SP1, and CRE enhancer elements, is required for
activation of the
cyclin D1 promoter by
PKC-alpha ... Deletion of the AP-1 enhancer element located at position -954 upstream from the initiation site abolished
PKC-alpha dependent activation of
cyclin D1 expression ... A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner, providing further evidence that AP-1 activity is required for
activation of the
cyclin D1 promoter by
PKC-alpha and PKC-epsilon
Pysz et al., Exp Cell Res 2009
(Intestinal Neoplasms) :
PKCalpha expression consistently ( a )
reduced steady-state levels of
cyclin D1 by a novel transcriptional mechanism not previously seen in non transformed cells, and ( b ) re-established the ability of PKC agonists to activate the translational repressor 4E-BP1 and inhibit cyclin D1 translation
Gwak et al., J Cell Mol Med 2009
(Colonic Neoplasms) :
Moreover,
PKC-alpha activation
repressed the expression of
cyclin D1 and c-myc, which are known beta-catenin target genes, and thus inhibited the growth of colon cancer cells
Du et al., Exp Lung Res 2010
(Asthma) :
The activation of
PKC alpha with phorbol myristate acetate ( PMA ), a PKC activator,
up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs