Gene interactions and pathways from curated databases and text-mining

◀ Back to CCND1

CCND1 — PRKCA

Text-mined interactions from Literome

Soh et al., J Biol Chem 2003 : Transient transfection studies with a series of 5'-deleted cyclin D1 promoter constructs showed that the proximal 964-base region, which contains AP-1, SP1, and CRE enhancer elements, is required for activation of the cyclin D1 promoter by PKC-alpha ... Deletion of the AP-1 enhancer element located at position -954 upstream from the initiation site abolished PKC-alpha dependent activation of cyclin D1 expression ... A dominant negative mutant of c-Jun inhibited activation of the cyclin D1 promoter in a concentration dependent manner, providing further evidence that AP-1 activity is required for activation of the cyclin D1 promoter by PKC-alpha and PKC-epsilon
Pysz et al., Exp Cell Res 2009 (Intestinal Neoplasms) : PKCalpha expression consistently ( a ) reduced steady-state levels of cyclin D1 by a novel transcriptional mechanism not previously seen in non transformed cells, and ( b ) re-established the ability of PKC agonists to activate the translational repressor 4E-BP1 and inhibit cyclin D1 translation
Gwak et al., J Cell Mol Med 2009 (Colonic Neoplasms) : Moreover, PKC-alpha activation repressed the expression of cyclin D1 and c-myc, which are known beta-catenin target genes, and thus inhibited the growth of colon cancer cells
Du et al., Exp Lung Res 2010 (Asthma) : The activation of PKC alpha with phorbol myristate acetate ( PMA ), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs