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CCR7 — PTGS2

Text-mined interactions from Literome

Liu et al., Mol Immunol 2007 : Considering the essential role in T cell tolerance of DC migration to secondary lymphoid organs, here we demonstrate that triptolide can significantly inhibit LPS triggered upregulation of CCR7 expression and PGE ( 2 ) production by inhibiting cyclooxygenase-2 (COX-2) expression in DC, thus impairing DC migration towards CCR7 ligand CCL19/MIP-3betain vitro
Pan et al., J Biol Chem 2008 (Breast Neoplasms...) : We found that treatment of prostaglandin E ( 2 ) or ectopic expression of COX-2 in MCF-7 cells up-regulated CCR7 expression ... We also found that COX-2 increased CCR7 expression via the EP2 and EP4 receptor in breast cancer cells ... Protein kinase A and AKT kinase were involved in COX-2 induced CCR7 ... Collectively, we suggest that CCR7 is a down-stream target for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion
Chuang et al., J Cell Physiol 2013 (Breast Neoplasms...) : In this study, we address the underlying mechanism of COX-2/PGE2 induced CCR7 expression