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RAD50 — RAPGEF3

Text-mined interactions from Literome

Maillet et al., Nat Cell Biol 2003 (Alzheimer Disease) : We also show that Rac activation results from activation of Rap1 through the cAMP guanine nucleotide-exchange factor (GEF) Epac1
Tiwari et al., Blood 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1 mediated Rap1 activation does not account for PDE4 inhibitor induced apoptosis
Moon et al., J Neurosci Res 2005 : Epac1 mediated Rap1 activation is not required for the production of nitric oxide in BV2, murine microglial cells ... This suggests that LPS stimulated NO production is mainly PKA dependent and also that Epac1 mediated Rap1 activation is not required for the induction of NO production
Wang et al., Mol Cell Biol 2006 : We confirm that the PKA independent activation of Rap1 by Epac1 activates a perinuclear pool of Rap1 and that this does not result in ERK activation
Bryn et al., J Immunol 2006 : In this study, we demonstrate the presence of Epac1 in human peripheral blood monocytes and activation of Rap1 in response to cAMP
Moon et al., Immunol Lett 2007 : Here, we investigated whether NF-kappaB can be activated by cAMP production through Epac1 mediated Rap1 activation by using Epac-specific cAMP analogue, 8- ( 4-chloro-phenylthio ) -2'-O-methyladenosine-3',5'-cyclic monophosphate ( CPT ) ... In conclusion, NF-kappaB activation should be regulated through Epac1 mediated Rap1 stimulation for LPS induced inflammatory responses in murine macrophages
Dremier et al., Endocrinology 2007 : The TSH induced activation of Rap1 was presumably mediated by Epac1 because it was mimicked by the Epac-selective cAMP analog ( 8-p-chloro-phenyl-thio-2'-O-methyl-cAMP ) and not by PKA-selective cAMP analogs
Brock et al., Exp Cell Res 2008 : The absence of Rap1 on late phagosomes suggests that the effect of Epac-1 might not require Rap1
Tsalkova et al., Proc Natl Acad Sci U S A 2012 : These EAPC2-specific antagonists, designated as ESI-05 and ESI-07, inhibit Rap1 activation mediated by EAPC2, but not EPAC1 , with high potency in vitro