Gene interactions and pathways from curated databases and text-mining

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RNF2 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Mol Cell 2009 : We further demonstrate that MOF-MSL1v1 is specifically required for optimal transcription activation of p53 target genes both in vitro and in vivo
Fu et al., Proc Natl Acad Sci U S A 2010 : We found that an E3 ubiquitin ligase RFWD3 ( RNF201/FLJ10520 ) forms a complex with Mdm2 and p53 to synergistically ubiquitinate p53 and is required to stabilize p53 in the late response to DNA damage
Su et al., Proc Natl Acad Sci U S A 2013 (Neoplasms...) : RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development ... The up-regulation of p53 does not affect RNF2 expression