UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MDM2

MDM2 — RPS3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: RPS3 — MDM2 (direct interaction, pull down) Yadavilli et al., DNA repair 2009 *
IRef Biogrid Interaction: RPS3 — MDM2 (physical association, affinity chromatography technology) Yadavilli et al., DNA repair 2009 *
IRef Biogrid Interaction: RPS3 — MDM2 (direct interaction, fluorescent resonance energy transfer) Yadavilli et al., DNA repair 2009 *

Text-mined interactions from Literome

Xiong et al., Oncogene 2011 : Several ribosomal proteins regulate p53 function by modulating MDM2
Daftuar et al., PloS one 2013 : Relevantly, a number of RPs have been shown to bind to MDM2 and inhibit MDM2 E3 ligase activity, leading to p53 stabilization and cell cycle arrest, thus revealing a RP-Mdm2-p53 signaling pathway that is critical for ribosome biogenesis surveillance