Gene interactions and pathways from curated databases and text-mining

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MTOR — RPS6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Mieulet et al., Am J Physiol Cell Physiol 2007 (Muscular Atrophy) : The phosphorylation of ribosomal protein S6 (rpS6) , eukaryotic initiation factor-4B (eIF4B), and eukaryotic elongation factor-2 ( eEF2 ) is predominantly regulated by mTOR in muscle cells
Li et al., J Immunol 2011 (HIV Infections...) : Targeted gene silencing of MyD88 ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition resulted in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Galbaugh et al., BMC cell biology 2006 : But lower levels of PI-3-K and mTOR inhibitors were required to block insulin induced phosphorylation of RPS6 than EGF induced phosphorylation, and insulin induced phosphorylation of elF4E and 4E-BP1 was not completely mTOR dependent suggesting some diversity of signaling for EGF and insulin
Villanueva et al., Endocrinology 2009 : To determine the mechanisms by which leptin modulates mTORC1 in specific hypothalamic neurons, we immunohistochemically assessed the mTORC1 dependent phosphorylation of ribosomal protein S6 (pS6)
Kimball et al., J Biol Chem 1999 : Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
Tuhácková et al., Int J Mol Med 2004 : IL2 dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells ... IL2 dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
Bonito-Oliva et al., Neuropharmacology 2013 : Haloperidol promotes mTORC1 dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1
Tamura et al., ISRN pharmacology 2013 : Rapamycin, an inhibitor of mTOR complex 1, reduced the level of HIF-1 a and blocked phosphorylation of ribosomal protein S6 kinase 1 (S6K) , a transcriptional regulator of mTOR , demonstrating that hypoxia activates mTOR/S6K/HIF-1 a signaling in CCA
Shao et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) : p70 ribosomal protein S6 kinase activity was induced by K-Ras in a PI3K- and mTOR dependent manner
Gundermann et al., J Appl Physiol 2012 (Hyperemia) : BFR exercise increased the phosphorylation of mTOR, S6 kinase 1, ribosomal protein S6 , ERK1/2, and Mnk1 interacting kinase 1 ( P < 0.05 ) with no changes in mTORC1 signaling in the SNP trial ( P > 0.05 )
Knaup et al., Mol Cancer Res 2009 : However, certain proteins are believed to be preferentially translated during hypoxia via 5 ' terminal oligopyrimidine tract mechanisms with controversial discussion about the involvement of the mTOR dependent ribosomal protein S6 (rpS6)