Gene interactions and pathways from curated databases and text-mining

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SDC2 — WNT6

Text-mined interactions from Literome

Dieudonné et al., Cancer Res 2010 (Bone Neoplasms...) : High Wnt signaling represses the proapoptotic proteoglycan syndecan-2 in osteosarcoma cells ... Wnt3a stimulation, beta-catenin activation, and TCF overexpression resulted in syndecan-2 repression, whereas Wnt inhibition using sFRP-1 increased syndecan-2 expression in U2OS cells ... These results indicate that Wnt/beta-catenin and Wnt/RhoA signaling contribute to syndecan-2 repression ... The high activity of the canonical Wnt pathway in the different osteosarcoma cells induces a constitutive repression of syndecan-2 transcription, whereas Wnt/RhoA signaling blocks the amplification loop of syndecan-2 expression
Dieudonné et al., J Bone Miner Res 2012 (Bone Neoplasms...) : We previously showed that Wnt/ß-catenin/T-cell factor ( TCF ) activation are responsible for the repression of syndecan-2 , a key modulator of apoptosis and chemosensitivity in osteosarcoma cells, suggesting a role of Wnt signaling in chemoresistance