Gene interactions and pathways from curated databases and text-mining

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SDHD — TNF

Text-mined interactions from Literome

Charlab et al., Lepr Rev 2001 : PGL-I alone did not induce TNF secretion by PBMC, but when associated with a sub-optimal dose of armadillo derived M. leprae increased the release of this cytokine ... This increase in TNF production suggests that PGL-I plays a role in the induction of TNF during the natural infection ... In addition, the modulatory effect of PGL-I on TNF release by THP-1 cells reinforces that monocytes are one of the possible targets of this molecule
Dhungel et al., Nepal Medical College journal : NMCJ 2008 (Leprosy) : This increase in TNF-alpha production suggests that PGL-I may play a significant role in the induction of TNF-alpha during natural infection