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SDHD — TNF
Text-mined interactions from Literome
Charlab et al., Lepr Rev 2001
:
PGL-I alone did not
induce TNF secretion by PBMC, but when associated with a sub-optimal dose of armadillo derived M. leprae increased the release of this cytokine ... This increase in TNF production suggests that
PGL-I plays a role in the induction of
TNF during the natural infection ... In addition, the modulatory
effect of
PGL-I on
TNF release by THP-1 cells reinforces that monocytes are one of the possible targets of this molecule
Dhungel et al., Nepal Medical College journal : NMCJ 2008
(Leprosy) :
This increase in TNF-alpha production suggests that
PGL-I may
play a significant role in the induction of
TNF-alpha during natural infection