Gene interactions and pathways from curated databases and text-mining

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CASP9 — SLC9A1

Text-mined interactions from Literome

Manucha et al., BJU Int 2007 (Ureteral Obstruction) : NHE1 inhibition by increasing doses of EIPA induced epithelial cell apoptosis and increased caspase-3 activity in a dose dependent manner
Jhumka et al., Int J Biochem Cell Biol 2009 : We report that the chemopreventive agent resveratrol ( RSV ) downregulates NHE-1 in a caspase dependent manner without inducing cell death ... RNAi mediated silencing of caspase 3 or 6 blocked the effect of resveratrol on NHE-1 expression, however the effect on NHE-1 promoter was observed at different phases of promoter repression with caspase 3 controlling the early phase ( 4-12 h ) and caspase 6 regulating the late phase ( 12-24 h )
Lauritzen et al., Exp Cell Res 2010 (Breast Neoplasms) : NHE1 inhibition augmented cisplatin induced caspase activity and lysosomal membrane permeability followed by cysteine cathepsin release