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SMAD2 — VEGFA

Text-mined interactions from Literome

Nakagawa et al., American journal of physiology. Renal physiology 2004 (Anoxia) : Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted VEGF at 24 h, and this was significantly reduced by blocking Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Kobayashi et al., Biochem Biophys Res Commun 2005 : These result suggest that TGF-beta1 stimulation of VEGF production by fibroblasts is regulated by Smad3 but not by Smad2 signaling
Yoshida et al., Cell Tissue Res 2007 : In vitro SEC differentiation, as indicated by the appearance of cells co-expressing SE-1 and stabilin-2 and of cells with cytoplasmic fenestrae in endothelial sheets, was induced by the addition of both VEGF and SB-431542, an inhibitor of the phosphorylation of Smad2/3 but not that of Smad1/5/8 in the cultured cells
Roest et al., Diabetes 2009 (Congenital Abnormalities...) : Furthermore, we investigated other possible mechanisms involved in this pathogenesis : alterations in the levels of vascular endothelial growth factor ( VEGF ) or phosphorylated Smad2 ( the latter can be induced by both glycation products and VEGF )
Mazzocca et al., Hepatology 2009 (Carcinoma, Hepatocellular...) : This effect was mediated by SMAD2/3 and affected the secretion of VEGF
Lee et al., Cell Tissue Res 2012 (Glomerulonephritis, Membranous...) : Furthermore, activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor and vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Bai et al., Development 2013 (Truncus Arteriosus, Persistent...) : Our findings indicate that Smad directly binds to Vegfa chromatin and represses Vegfa transcriptional activity