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RAC2 — SOS1

Pathways - manually collected, often from reviews:

• Reactome Reaction: RAC2 → SOS1 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Text-mined interactions from Literome

Innocenti et al., J Cell Biol 2002 : Thus, the involvement of Sos-1 at two distinct and differentially regulated steps of the signaling cascade allows for coordinated activation of Ras and Rac and different duration of their signaling within the cell
Sini et al., Nat Cell Biol 2004 : Abl dependent tyrosine phosphorylation of Sos-1 mediates growth-factor induced Rac activation
Silver et al., Genesis 2004 : These alleles provide new tools for future investigations of SOS mediated activation of both RAS and RAC and how these dual roles are coordinated and coregulated during development