Gene interactions and pathways from curated databases and text-mining

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CHUK — SPP1

Text-mined interactions from Literome

Das et al., J Biol Chem 2003 (Breast Neoplasms) : However, both pharmacological ( wortmannin and LY294002 ) and genetic ( Deltap85 ) inhibitors of PI 3'-kinase inhibited OPN induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha
Rangaswami et al., J Biol Chem 2004 (MAP Kinase Signaling System...) : Here we report that OPN induced alpha(v)beta(3) integrin mediated phosphorylation and activation of nuclear factor inducing kinase ( NIK ) and enhanced the interaction between phosphorylated NIK and IKKalpha/beta in B16F10 cells
Fong et al., Lung Cancer 2009 (Adenocarcinoma...) : Stimulation of A549 cells with OPN also induced IkappaB kinase alpha/beta ( IKK alpha/beta ) phosphorylation, IkappaBalpha phosphorylation, p65 Ser ( 536 ) phosphorylation, and kappaB-luciferase activity