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IL6 — STAT5A

Text-mined interactions from Literome

Yu et al., J Immunol 1999 : Moreover, the STAT element was shown to bind STAT5a/b induced by IL-2 as well as STAT1alpha induced by IL-6 in human NK cells
Schumann et al., J Neurochem 1999 (Neuroblastoma) : IL-6 induced activation and translocation of STAT3 and to a lesser degree STAT1 but not STAT5 are demonstrated
Pratt et al., Shock 2000 (Colonic Neoplasms) : Tyrosine phosphorylation of both Stat5a and Stat5b was induced by IL-6
Klausen et al., Oncogene 2000 : Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation, while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation
Kawashima et al., J Immunol 2001 (Leukemia, Myeloid, Acute) : STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65 ... We also found that the STAT5A1*6 transactivated the IL-6 promoter, which was mediated by the enhanced binding of NF-kappaB p65 ( RelA ) to the promoter region of IL-6
Klein et al., Shock 2003 (Burns...) : The changes in cytokine profiles after burn, particularly interleukin-1beta and macrophage inhibitory factor, appear to be mediated by C/EBP-beta and STAT-3, whereas after the induction of a sepsis, tumor necrosis factor and interleukin-6 are mainly mediated by STAT-5
Kimura et al., Proc Natl Acad Sci U S A 2005 : Furthermore, AG490, a Jak-specific inhibitor, and dominant negative Stat5 only reduced LPS induced IL-6 production
Liby et al., Clin Cancer Res 2006 (Lung Neoplasms...) : We now report that CDDO-Imidazolide, previously shown to be a potent agent for control of inflammation, cell proliferation, and apoptosis, rapidly ( within 30-60 minutes ) and potently ( at nanomolar levels ) suppresses either constitutive or interleukin-6 induced STAT3 and STAT5 phosphorylation in human myeloma and lung cancer cells
Lang et al., Clin Cancer Res 2007 (Neovascularization, Pathologic...) : Hypoxia- and IL-6 mediated activation of HIF-1alpha or STAT3/STAT5 were substantially inhibited by 17-AAG
Varin et al., Exp Gerontol 2008 : Human peripheral blood mononuclear cells ( PBMC ) were obtained from heparinized blood and were stimulated in vitro by IL-2 or IL-6 for various periods and the phosphorylation of STAT3 and STAT5 was measured by FACScan
Lee et al., J Immunol 2011 : Progesterone enhanced activation of STAT5 in response to IL-2, whereas it decreased STAT3 activation in response to IL-6 , which is in line with the selective activity of progesterone in generation of Tregs versus Th17 cells
Xu et al., J Interferon Cytokine Res 2012 : In the present study, we for the first time identified that in human hepatoma cell line HepG2 the activation of FXR by the natural agonist chenodeoxycholic acid ( CDCA ) and the synthetic specific agonist GW4064 upregulated CISH at both transcriptional and translational levels, and inhibited interleukin (IL)6 induced STAT5 activation
Tormo et al., Cytokine 2012 : IL-6 activates STAT5 in T cells ... The results show that IL-6 also induces STAT5 activation in both CD4 and CD8 T as well as NK cells
Hoefsloot et al., Blood 1997 (Myelodysplastic Syndromes) : In contrast, interleukin-3 induced a normal STAT5 response in MDS cells
Piekorz et al., Biochem Biophys Res Commun 1997 (Carcinoma, Hepatocellular...) : Here we report that leukemia inhibitory factor (LIF) and IL-6 activate Stat5a in M1 myeloid leukemia cells in addition
Ozaki et al., Blood 1998 : Furthermore, interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and erythropoietin also induce Crkl-STAT5 complex formation in responding cells in a stimulation dependent manner