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SUZ12 — YY1

Text-mined interactions from Literome

Pasini et al., EMBO J 2004 : Furthermore, we demonstrate that SUZ12 is essential for the activity and stability of the PRC2/3 complexes in mouse embryos, in tissue culture cells and in vitro ... In conclusion, our data demonstrate an essential role of SUZ12 in regulating the activity of the PRC2/3 complexes, which are required for regulating proliferation and embryogenesis
Hernández-Muñoz et al., Mol Cell Biol 2005 : Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1
Furuno et al., Biochem Biophys Res Commun 2006 : Although the essential role of SUZ12 in regulating the activity of the PRC2/3 complexes has been demonstrated, additional function of this protein was suggested
Schoeftner et al., EMBO J 2006 : Xist expression early in ES cell differentiation establishes a chromosomal memory, which allows efficient H2A ubiquitination in differentiated cells and is independent of silencing and PRC2
Ohno et al., Mech Dev 2008 : Finally, using zygotic mutations in both genes, we show that the gradual loss of function of PRC2 activity leads first to a loss of histone H3 K27 methylation and only at a later stage to a gradual loss of PRC1 binding to chromatin
De Lucia et al., Proc Natl Acad Sci U S A 2008 : The PHD-PRC2 activity increases H3K27me3 throughout the locus to levels sufficient for stable silencing
Margueron et al., Mol Cell 2008 : While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly
Tang et al., Acta Biochim Biophys Sin (Shanghai) 2009 : Here, we try to reveal how PRC2, PRC2 mediated repressive histone marker H3K27me3 , and active histone marker histone H4 acetylation ( acH4 ) regulate the CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... Here, we try to reveal how PRC2 , PRC2 mediated repressive histone marker H3K27me3, and active histone marker histone H4 acetylation ( acH4 ) regulate the CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... These results suggested that the histone modification including PRC2 mediated repressive histone marker H3K27me3 and active histone marker acH4 may involve in CD11b transcription during HL-60 leukemia cells reprogramming to terminal differentiation
Zhang et al., J Biol Chem 2009 : Our results suggest that reduced expression of PRC2 component genes in cloned embryos results in defective modification of H3K27me3 to the differentiation related genes in pluripotent ICM cells
Seong et al., Hum Mol Genet 2010 (Disease Models, Animal...) : Supporting a direct stimulatory role, full-length recombinant huntingtin significantly increased the histone H3K27 tri-methylase activity of reconstituted PRC2 in vitro, and structure-function analysis demonstrated that the polyglutamine region augmented full-length huntingtin PRC2 stimulation, both in Hdh ( Q111 ) EBs and in vitro, with reconstituted PRC2
Shen et al., Cell 2009 : In vitro JMJ inhibits PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically, JMJ is required for efficient binding of PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Li et al., Genes Dev 2010 : Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as Jarid2 knockdown reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access
Negishi et al., PloS one 2010 : Levels of both Zfp277 and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs, but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant restored the binding of PRC2 but not PRC1 to the Ink4a/Arf locus
Tae et al., Nucleic Acids Res 2011 (Leukemia...) : Furthermore, inhibition of BRD7 expression reduces PRMT5 and PRC2 recruitment to ST7 and RBL2 promoters ; however, only ST7 becomes transcriptionally derepressed
Schmitges et al., Mol Cell 2011 : In addition to H3K4me3, PRC2 is inhibited by H3K36me2/3 ( i.e., both H3K36me2 and H3K36me3 )
Zhou et al., Blood 2011 (Leukemia, Myeloid, Acute) : We show that disruption of PRC2 , either by DZNep treatment or EZH2 knockdown, reactivates TXNIP, inhibits thioredoxin activity, and increases reactive oxygen species ( ROS ), leading to apoptosis
Zhang et al., J Biol Chem 2011 : We show that CDYL dramatically enhances the methyltransferase activity of PRC2 toward oligonucleosome substrates in vitro ... CDYL is required for chromatin targeting and maximal enzymatic activity of PRC2 at their common target sites
Neri et al., Mol Cell Biol 2012 : Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells
He et al., PLoS Genet 2012 : One possible role of PRC2 mediated H3K27me3 in the leaf-to-callus transition might relate to elimination of leaf features by silencing leaf-regulatory genes, as most leaf-preferentially expressed regulatory genes could not be silenced in the leaf explants of clf swn
Duan et al., Prostate 2013 (Prostatic Neoplasms) : While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and involves E2F and histone H3K4me3 methylase MLL1 complex
Ballaré et al., Nature structural & molecular biology 2012 : These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells ... These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells
Hidalgo et al., Cell stem cell 2012 : Epigenomic and gene expression changes induced by Ezh1 deletion in senesced HSCs demonstrated that Ezh1 mediated PRC2 activity catalyzes monomethylation and dimethylation of H3K27
Cai et al., Mol Cell 2013 : Ectopically expressed PHF1 induced Tudor dependent stabilization of PRC2 complexes on bulk chromatin and mediated spreading of PRC2 and H3K27me3 into H3K36me3 containing chromatin regions
Chan et al., Stem Cells 2013 : Depletion of PRDM14 reduces PRC2 binding at these loci and the concomitant reduction of H3K27me3 modification ... In addition, we show that PRDM14 recruits PRC2 to repress a key mesenchymal gene ZEB1 , which enhances mesenchymal-to-epithelial transition in the initiation event of iPSC reprogramming
Fragola et al., PLoS Genet 2013 : These results indicate that PRC2 mediated H3K27 trimethylation is required on a highly selective core of Polycomb targets whose repression enables TF-dependent cell reprogramming
Aldiri et al., Development 2013 (Wnt Signaling Pathway) : We also show that Wnt/ß-catenin signaling acting through the receptor Frizzled 5, but independent of Sox2, regulates expression of key PRC2 subunits in the developing retina
Derkacheva et al., EMBO J 2013 : While p55 is not essential for the in vitro enzymatic activity of PRC2 , plant MSI1 was required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower ... While p55 is not essential for the in vitro enzymatic activity of PRC2, plant MSI1 was required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower