Gene interactions and pathways from curated databases and text-mining

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CASP4 — TCHP

Text-mined interactions from Literome

Cho et al., J Korean Med Sci 2001 : When HL-60 cells, p53 null, were treated with etoposide, MDM2 was markedly decreased prior to caspase-3 dependent retinoblastoma tumor suppressor protein ( pRb ) and poly ( ADP- ribose ) polymerase ( PARP ) cleavages
Ollinger et al., Cell cycle (Georgetown, Tex.) 2007 : The signaling cascades responsible for this action involved induction of p53, p27, hypophosphorylation of the retinoblastoma tumor suppressor protein as well as caspase activation
Kim et al., Mol Cell 2008 : A tumor suppressor protein , PHAPI, enhances caspase-9 activation by promoting apoptosome formation through an unknown mechanism