Gene interactions and pathways from curated databases and text-mining

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TGFB2 — TNF

Text-mined interactions from Literome

Verrecchia et al., J Biol Chem 2000 : Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1, tumor necrosis factor , or vehicle in the presence or absence of transforming growth factor-beta
Langhorne et al., Immunol Rev 2004 (Inflammation...) : IFN-gamma and TNF-alpha play a role in both protective immunity and the pathology of the infection, and the inflammatory disease may be regulated by IL-10 and transforming growth factor-beta
Kaneki et al., J Biol Chem 2006 : TNF inhibited the expression of bone morphogenetic protein and transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
Li et al., J Biol Chem 2006 : Surprisingly, this brief exposure to FC-AMs triggered a modest proinflammatory response in the phagocytes : tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1beta were induced , whereas the levels of transforming growth factor-beta and IL-10 were not increased
Nagineni et al., J Cell Physiol 2007 : RT-PCR analyses showed that TNF-alpha and IL-1beta increased the mRNA levels of both TGF-beta1 and TGF-beta2
Satoh et al., J Cell Physiol 1992 : Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor beta and interleukin 6
Srivastava et al., J Biol Chem 2007 : TNF-alpha increased the activity of transforming growth factor-beta activating kinase-1 ( TAK1 )
Gómez et al., FEMS Immunol Med Microbiol 2008 : Cytokines are an integral component of the adaptive and innate immune response, particularly IL-1 beta, interferon, tumor necrosis factor-alpha , transforming growth factor-beta and several chemokines regulate innate immunity
Bekeredjian-Ding et al., Immunology 2009 (Head and Neck Neoplasms) : Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha ( IFN-alpha ) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC
Dunham et al., J Leukoc Biol 1990 : Role of interferon-gamma in counteracting the suppressive effects of transforming growth factor-beta 2 and glucocorticoids on the production of tumor necrosis factor-alpha
Brennan et al., Clin Exp Immunol 1990 (Arthritis, Rheumatoid) : This was confirmed by the observation that neither TGF-beta 1 or TGF-beta 2 inhibited spontaneous IL-1 or TNF-alpha production by rheumatoid synovial mononuclear cells in culture
Cockerill et al., Lab Invest 1994 (Trisomy) : CD34 expression of this cell line and the ability of transforming growth factor-beta to inhibit the TNF-alpha induction of E-selectin was examined ... C11STH cells do not express CD34 or show transforming growth factor-beta inhibition of TNF-alpha induced E-selectin expression, functions indicative of primary, or early passage HUVECs
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Chao et al., Clin Immunol Immunopathol 1995 : Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures
Campbell et al., Biochim Biophys Acta 1994 (Joint Diseases) : Tumor necrosis factor alpha (TNF alpha) reduced, and transforming growth factor-beta ( TGF-beta ) and basic fibroblast growth factor (bFGF) increased , the levels of PAI-1 antigen and mRNA in the culture fluids and cell extracts, respectively
Barnum et al., J Immunol 1994 (Inflammation) : In this report, we show that transforming growth factor-beta ( TGF-beta ) can significantly inhibit the capacity of IFN-gamma, IL-1 beta, and TNF-alpha to augment expression of the central component of complement C3 in the human astroglioma cell line D54-MG. Treatment of D54-MG cells with TGF-beta alone had no dose- or time dependent effect on basal C3 protein or mRNA levels
Offner et al., Am J Pathol 1996 : Neither tumor necrosis factor (TNF)-alpha nor interferon (IFN)-gamma ( both 10 ng/ml ) affected TGF-beta 1 or TGF-beta 2 synthesis by HPMCs. TGF-beta 3 could not be detected in any of the supernatant media
Nishida et al., Am J Kidney Dis 1997 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of interleukin-6, platelet derived growth factor, and transforming growth factor-beta by mesangial cells, whereas tumor necrosis factor-alpha secretion was stimulated by oxidized LDL
Fortunato et al., Am J Obstet Gynecol 1997 (Obstetric Labor, Premature) : Interleukin-10 and transforming growth factor-beta inhibit amniochorion tumor necrosis factor-alpha production by contrasting mechanisms of action : therapeutic implications in prematurity ... This study was designed to detect the regulatory effect of the immunoinhibitory cytokines interleukin-10 and transforming growth factor-beta on the amniochorion production of tumor necrosis factor-alpha ... This study suggests that interleukin-10 and transforming growth factor-beta can regulate tumor necrosis factor-alpha release from amniochorion under different conditions and by a different mechanism
Méndez-Samperio et al., Clin Diagn Lab Immunol 1998 (Tuberculosis, Pulmonary) : The effect of exogenous transforming growth factor beta ( TGF-beta ) on Mycobacterium bovis BCG induced tumor necrosis factor alpha (TNF-alpha) production by human mononuclear cells was studied
Danforth et al., Clin Cancer Res 1996 (Breast Neoplasms) : We studied the effect of tumor necrosis factor alpha (TNF-alpha) on transforming growth factor beta ( TGF-beta ) secretion by human breast cell lines to further characterize the antitumor effects of TNF-alpha