◀ Back to TRAF6
TLR5 — TRAF6
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TLR5
→
TRAF6
(reaction)
Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Kollewe et al., J Biol Chem 2004, Gottipati et al., Cell Signal 2008, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996
-
Reactome Reaction:
TLR5
→
TRAF6
(indirect_complex)
Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996
-
WikiPathways Simplified Depiction of MYD88 Distinct Input-Output Pathway:
TLR1/TLR2/TLR4/TLR5/TLR6/TLR7/TLR8/TLR9/TLR10/IL1A
→
Complex of UBE2N-UBE2V1-TRAF6-TIFA-IRAK1
(activation)
Text-mined interactions from Literome
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88, IRAK,
TRAF6 , and Toll interacting protein (Tollip), but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Leppert et al., J Immunol 2007
:
The soluble variant surface glycoprotein of African trypanosomes is recognized by a macrophage scavenger receptor and induces I kappa B alpha degradation independently of
TRAF6 mediated
TLR signaling ... Activation of RAW 264.7 cells by sVSG following treatment of the cells with the TRAF6 inhibitory peptide DIVK resulted in enhanced NF-kappaB signaling, suggesting both that
TRAF6 dependent
TLR activation of the pathway alone is not required for signaling and that TLR pathway components may negatively regulate expression of sVSG induced signaling
Clark et al., Proc Natl Acad Sci U S A 2011
:
Toll-like receptor ( TLR ) ligands that signal via TIR-domain containing adapter inducing IFNß ( TRIF )
activate the I?B kinase ( IKK ) -related kinases,
TRAF associated NF?B activator ( TANK) binding kinase-1 (TBK1 ) and IKKe, which then phosphorylate IRF3 and induce the production of IFNß
Jono et al., PloS one 2012
(MAP Kinase Signaling System) :
PKC? synergizes with
TLR dependent
TRAF6 signaling pathway to upregulate MUC5AC mucin via CARMA1
Inomata et al., Biochem Biophys Res Commun 2013
:
Furthermore, Atg5 deficiency increased formation of the
MyD88-TRAF6 signaling complex
induced by
TLR stimulation, and it enhanced activation of NF-?B signaling but not MAPKs and Akt