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HNRNPF — VEGFA
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Kang et al., Leukemia & lymphoma 2006
(Leukemia) :
We examined the
effect of cellular
vascular endothelial growth factor ( VEGF ) levels on the generation of leukemic
dendritic cells (DCs) ... AML cells that failed to generate leukemic DCs showed significantly higher cellular VEGF levels compared with generated leukemic DCs, and down-regulation of cellular
VEGF levels
induced the generation of leukemic
DCs from AML cells ... Inhibition of cellular
VEGF levels
increased interleukin (IL)-12 production and the allostimulatory capacity of leukemic
DCs ... These results suggest that the generation of leukemic
DCs from AML cells is inversely related to the VEGF production of the cells and that the down-regulation of cellular
VEGF levels can
induce potential differentiation of leukemic cells to functional leukemic DCs in patients with AML
Mimura et al., Cancer Immunol Immunother 2007
:
To investigate the effects of VEGF against human mature DCs, we investigated how
VEGF affects mature
DCs with regards to phenotype, induction of apoptosis, IL-12 ( p70 ) production and the antigen presenting function evaluated by allogeneic mixed leukocyte reaction ( allo-MLR )
Lu et al., Cell Biochem Funct 2011
:
VEGF-A induced immature
DCs not mature DCs differentiation into endothelial-like cells through ERK1/2 dependent pathway
Liu et al., Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2012
:
In vitro,
VEGF and TGF-ß1 strongly interfered with DC maturation and consequently
led to immature
DCs , which secreted high levels of IL-10 that accumulated around the tumor site