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CD79B — XRCC6

Text-mined interactions from Literome

Gold et al., Immunol Rev 2000 : In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling ... We showed that the BCR activates Rap1 via phospholipase C-dependent production of diacylglycerol
Mizuchi et al., Biochem Biophys Res Commun 2005 : Here we demonstrate that the inducible expression of BCR/ABL in a murine hematopoietic cell line, TonB210, leads to the activation of the Ras family small GTPase Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
McLeod et al., J Biol Chem 1998 : In this report, we show that BCR engagement activates Rap1 and that this is dependent on production of diacylglycerol ( DAG ) by phospholipase C-gamma ... However, the DAG dependent pathway by which the BCR activates Rap1 apparently does not involve Crk signaling complexes since phorbol dibutyrate could activate Rap1 without inducing the formation of these complexes ... Thus, the BCR activates Rap1 via a novel DAG dependent pathway