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Yoon et al., J Biol Chem 2007
(Breast Neoplasms) :
In addition, the activation of mTOR by the overexpression of RHEB in MDA-MB-231 cells increased the synthetic rates of both FASN and ACCalpha
Lin et al., J Agric Food Chem 2010
(Breast Neoplasms) :
The use of Akt-overexpression revealed that the modulation of Akt and mTOR was required for osthole induced FASN suppression
Lee et al., Phytother Res 2013
(Breast Neoplasms) :
The use of pharmacological inhibitors revealed that the modulation of AKT, mTOR , and JNK phosphorylation required synergistic amentoflavone induced FASN inhibition and HER2 activation in SKBR3 cells