Description: Homo sapiens fibroblast growth factor 4 (FGF4), mRNA. RefSeq Summary (NM_002007): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr11:69,587,797-69,590,171 Size: 2,375 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr11:69,588,077-69,589,852 Size: 1,776 Coding Exon Count: 3
ID:FGF4_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 4; Short=FGF-4; AltName: Full=Heparin secretory-transforming protein 1; Short=HST; Short=HST-1; Short=HSTF-1; AltName: Full=Heparin-binding growth factor 4; Short=HBGF-4; AltName: Full=Transforming protein KS3; Flags: Precursor; FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. SUBUNIT: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Belongs to the heparin-binding growth factors family.
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FGF4 CDC HuGE Published Literature: FGF4 Positive Disease Associations: Diabetes Mellitus, Type 1 Related Studies:
Diabetes Mellitus, Type 1 Jonathan P Bradfield et al. PLoS genetics 2011, A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci., PLoS genetics.
[PubMed 21980299]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08620
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.