Description: Homo sapiens glucosidase, alpha; neutral AB (GANAB), transcript variant 3, mRNA. RefSeq Summary (NM_198335): This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr11:62,392,298-62,414,198 Size: 21,901 Total Exon Count: 25 Strand: - Coding Region Position: hg19 chr11:62,393,287-62,414,071 Size: 20,785 Coding Exon Count: 25
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14697-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00510 - N-Glycan biosynthesis hsa01100 - Metabolic pathways
BioCarta from NCI Cancer Genome Anatomy Project h_eradPathway - ER¿associated degradation (ERAD) Pathway
Reactome (by CSHL, EBI, and GO)
Protein Q14697 (Reactome details) participates in the following event(s):
R-HSA-532667 Removal of the second glucose by glucosidase II R-HSA-548890 Removal of the third glucose by glucosidase II and release from the chaperone R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-901042 Calnexin/calreticulin cycle R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
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