Human Gene ADGRF4 (uc003oyz.1)
  Description: Homo sapiens G protein-coupled receptor 115 (ADGRF4), mRNA.
RefSeq Summary (NM_153838): Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016].
Transcript (Including UTRs)
   Position: hg19 chr6:47,653,600-47,686,181 Size: 32,582 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr6:47,653,600-47,686,178 Size: 32,579 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:47,653,600-47,686,181)mRNA (may differ from genome)Protein (752 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP115_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 115; AltName: Full=G-protein coupled receptor PGR18; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SEQUENCE CAUTION: Sequence=AAN46671.1; Type=Erroneous gene model prediction; Sequence=BAC45257.1; Type=Erroneous gene model prediction; Sequence=CAI15579.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.84 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 79.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017981 - GPCR_2-like
IPR008078 - GPCR_2_Ig-hepta_rcpt
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif

ModBase Predicted Comparative 3D Structure on Q8IZF3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  DQ315369 - Homo sapiens G protein-coupled receptor 111 (GPR111) mRNA, complete cds.
AK126683 - Homo sapiens cDNA FLJ44729 fis, clone BRACE3024879.
AY140957 - Homo sapiens G-protein coupled receptor GPR115 (GPR115) mRNA, complete cds.
AK095395 - Homo sapiens cDNA FLJ38076 fis, clone CTONG2015866, highly similar to Probable G-protein coupled receptor 115.
DQ315370 - Homo sapiens clone IMAGE:8317335 G protein-coupled receptor 115 (GPR115) mRNA, complete cds.
BC156187 - Synthetic construct Homo sapiens clone IMAGE:100061573, MGC:190033 G protein-coupled receptor 115 (GPR115) mRNA, encodes complete protein.
BC156924 - Synthetic construct Homo sapiens clone IMAGE:100063625, MGC:190798 G protein-coupled receptor 115 (GPR115) mRNA, encodes complete protein.
AY255556 - Homo sapiens G protein-coupled receptor PGR18, mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AY140957, B3KTD0, GP115_HUMAN, GPR115, NM_153838, NP_722580, PGR18, Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6, Q8IZF3
UCSC ID: uc003oyz.1
RefSeq Accession: NM_153838
Protein: Q8IZF3 (aka GP115_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY140957.1
exon count: 10CDS single in 3' UTR: no RNA size: 2259
ORF size: 2259CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3901.00frame shift in genome: no % Coverage: 99.87
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.