Description: Homo sapiens lectin, galactoside-binding, soluble, 2 (LGALS2), mRNA. RefSeq Summary (NM_006498): The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr22:37,966,253-37,976,024 Size: 9,772 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr22:37,966,270-37,975,912 Size: 9,643 Coding Exon Count: 4
Antidepressive Agents S L Clark et al. Psychological medicine 2012, Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D., Psychological medicine.
[PubMed 22041458]
Although our findings require replication and functional validation, this study demonstrates the potential of GWAS to discover genes and pathways that could mediate adverse effects of antidepressant medication.
myocardial infarct Koch, W. et al. 2007, Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans, Hum Mol Genet 2007.
[PubMed 17517687]
Myocardial Infarction Ozaki K 2004, Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro., Nature. 2004 May;429(6987):72-5.
[PubMed 15129282]
Our findings thus suggest a link between the LTA cascade and the pathogenesis of MI.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05162
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.