Description: Homo sapiens MOK protein kinase (MOK), transcript variant 1, mRNA. RefSeq Summary (NM_014226): This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]. Transcript (Including UTRs) Position: hg19 chr14:102,695,158-102,771,537 Size: 76,380 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr14:102,695,626-102,771,305 Size: 75,680 Coding Exon Count: 12
ID:MOK_HUMAN DESCRIPTION: RecName: Full=MAPK/MAK/MRK overlapping kinase; EC=2.7.11.22; AltName: Full=MOK protein kinase; AltName: Full=Renal tumor antigen 1; Short=RAGE-1; FUNCTION: Able to phosphorylate several exogenous substrates and to undergo autophosphorylation (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Phosphorylation appears to increase the enzymatic activity (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina. PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAB38087.1; Type=Frameshift; Positions=299;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q9UQ07
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
