Description: Homo sapiens prospero homeobox 1 (PROX1), transcript variant 1, mRNA. RefSeq Summary (NM_001270616): The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]. Transcript (Including UTRs) Position: hg19 chr1:214,161,278-214,214,847 Size: 53,570 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr1:214,169,879-214,209,177 Size: 39,299 Coding Exon Count: 4
ID:PROX1_HUMAN DESCRIPTION: RecName: Full=Prospero homeobox protein 1; AltName: Full=Homeobox prospero-like protein PROX1; Short=PROX-1; FUNCTION: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity). INTERACTION: P56545:CTBP2; NbExp=2; IntAct=EBI-3912635, EBI-741533; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. SIMILARITY: Belongs to the Prospero homeobox family. SIMILARITY: Contains 1 Prospero-type homeobox DNA-binding domain. SEQUENCE CAUTION: Sequence=CAI15309.1; Type=Erroneous gene model prediction;
fasting glucose-related traits Dupuis ,et al. Nat Genet 2010, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , Nature genetics 2010 42- 2 : 105-16.
[PubMed 20081858]
fasting glucose-related traits Dupuis ,et al. Nat Genet 2010, New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , Nature genetics 2010 42- 2 : 105-16.
[PubMed 20081858]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92786
Front
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0016922 ligand-dependent nuclear receptor binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0050692 DBD domain binding GO:0050693 LBD domain binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001709 cell fate determination GO:0001822 kidney development GO:0001889 liver development GO:0001938 positive regulation of endothelial cell proliferation GO:0001945 lymph vessel development GO:0001946 lymphangiogenesis GO:0002088 lens development in camera-type eye GO:0002089 lens morphogenesis in camera-type eye GO:0002194 hepatocyte cell migration GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007275 multicellular organism development GO:0007420 brain development GO:0007623 circadian rhythm GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0010468 regulation of gene expression GO:0010595 positive regulation of endothelial cell migration GO:0021516 dorsal spinal cord development GO:0021542 dentate gyrus development GO:0021707 cerebellar granule cell differentiation GO:0021915 neural tube development GO:0030182 neuron differentiation GO:0030240 skeletal muscle thin filament assembly GO:0030324 lung development GO:0030910 olfactory placode formation GO:0031016 pancreas development GO:0031667 response to nutrient levels GO:0042752 regulation of circadian rhythm GO:0043049 otic placode formation GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045071 negative regulation of viral genome replication GO:0045446 endothelial cell differentiation GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045787 positive regulation of cell cycle GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046619 optic placode formation involved in camera-type eye formation GO:0048511 rhythmic process GO:0048839 inner ear development GO:0048845 venous blood vessel morphogenesis GO:0055005 ventricular cardiac myofibril assembly GO:0055007 cardiac muscle cell differentiation GO:0055009 atrial cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060042 retina morphogenesis in camera-type eye GO:0060059 embryonic retina morphogenesis in camera-type eye GO:0060214 endocardium formation GO:0060298 positive regulation of sarcomere organization GO:0060412 ventricular septum morphogenesis GO:0060414 aorta smooth muscle tissue morphogenesis GO:0060421 positive regulation of heart growth GO:0060836 lymphatic endothelial cell differentiation GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment GO:0061114 branching involved in pancreas morphogenesis GO:0070309 lens fiber cell morphogenesis GO:0070365 hepatocyte differentiation GO:0070858 negative regulation of bile acid biosynthetic process GO:0072574 hepatocyte proliferation GO:0090425 acinar cell differentiation GO:0097150 neuronal stem cell population maintenance GO:1901978 positive regulation of cell cycle checkpoint GO:2000179 positive regulation of neural precursor cell proliferation GO:2000979 positive regulation of forebrain neuron differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
