Human Gene PRR5L (uc001mwp.3)
  Description: Homo sapiens proline rich 5 like (PRR5L), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr11:36,397,535-36,486,754 Size: 89,220 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr11:36,422,672-36,484,286 Size: 61,615 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:36,397,535-36,486,754)mRNA (may differ from genome)Protein (368 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PRR5L_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 5-like; AltName: Full=Protein observed with Rictor-2; Short=Protor-2;
FUNCTION: May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
SUBUNIT: May replace PRR5 in the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR.
SIMILARITY: Belongs to the PROTOR family.
SEQUENCE CAUTION: Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRR5L
CDC HuGE Published Literature: PRR5L
Positive Disease Associations: Alcoholism , Creatinine
Related Studies:
  1. Alcoholism
    , , . [PubMed 0]
  2. Creatinine
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.68 RPKM in Spleen
Total median expression: 80.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -160.00375-0.427 Picture PostScript Text
3' UTR -813.502468-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013745 - HbrB

Pfam Domains:
PF08539 - HbrB-like

ModBase Predicted Comparative 3D Structure on Q6MZQ0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding

Biological Process:
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0009968 negative regulation of signal transduction
GO:0010762 regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0034599 cellular response to oxidative stress
GO:0038203 TORC2 signaling
GO:0061014 positive regulation of mRNA catabolic process
GO:0090316 positive regulation of intracellular protein transport

Cellular Component:
GO:0031932 TORC2 complex


-  Descriptions from all associated GenBank mRNAs
  AK055042 - Homo sapiens cDNA FLJ30480 fis, clone BRAWH1000174, moderately similar to Rho-GTPase-activating protein 8.
BX640959 - Homo sapiens mRNA; cDNA DKFZp686N03132 (from clone DKFZp686N03132).
AK024275 - Homo sapiens cDNA FLJ14213 fis, clone NT2RP3003572.
JD402944 - Sequence 383968 from Patent EP1572962.
BC008922 - Homo sapiens protor-2, mRNA (cDNA clone IMAGE:3659247), complete cds.
BC125122 - Homo sapiens protor-2, mRNA (cDNA clone IMAGE:40118977), partial cds.
JD126800 - Sequence 107824 from Patent EP1572962.
JD072526 - Sequence 53550 from Patent EP1572962.
JD393364 - Sequence 374388 from Patent EP1572962.
JD553711 - Sequence 534735 from Patent EP1572962.
JD264234 - Sequence 245258 from Patent EP1572962.
JD503824 - Sequence 484848 from Patent EP1572962.
JD487085 - Sequence 468109 from Patent EP1572962.
JD247883 - Sequence 228907 from Patent EP1572962.
JD101757 - Sequence 82781 from Patent EP1572962.
JD174131 - Sequence 155155 from Patent EP1572962.
JD431578 - Sequence 412602 from Patent EP1572962.
JD527049 - Sequence 508073 from Patent EP1572962.
JD251163 - Sequence 232187 from Patent EP1572962.
JD275578 - Sequence 256602 from Patent EP1572962.
JD378781 - Sequence 359805 from Patent EP1572962.
JD546724 - Sequence 527748 from Patent EP1572962.
JD181390 - Sequence 162414 from Patent EP1572962.
JD346870 - Sequence 327894 from Patent EP1572962.
JD310195 - Sequence 291219 from Patent EP1572962.
JD240750 - Sequence 221774 from Patent EP1572962.
JD324352 - Sequence 305376 from Patent EP1572962.
JD414256 - Sequence 395280 from Patent EP1572962.
JD433318 - Sequence 414342 from Patent EP1572962.
JD158056 - Sequence 139080 from Patent EP1572962.
JD382715 - Sequence 363739 from Patent EP1572962.
JD259342 - Sequence 240366 from Patent EP1572962.
JD216364 - Sequence 197388 from Patent EP1572962.
JD053516 - Sequence 34540 from Patent EP1572962.
JD338237 - Sequence 319261 from Patent EP1572962.
JD523891 - Sequence 504915 from Patent EP1572962.
JD074691 - Sequence 55715 from Patent EP1572962.
JD285628 - Sequence 266652 from Patent EP1572962.
JD375849 - Sequence 356873 from Patent EP1572962.
JD231278 - Sequence 212302 from Patent EP1572962.
JD333477 - Sequence 314501 from Patent EP1572962.
JD156565 - Sequence 137589 from Patent EP1572962.
JD454711 - Sequence 435735 from Patent EP1572962.
JD289604 - Sequence 270628 from Patent EP1572962.
JD258576 - Sequence 239600 from Patent EP1572962.
JD218743 - Sequence 199767 from Patent EP1572962.
JD042967 - Sequence 23991 from Patent EP1572962.
JD437435 - Sequence 418459 from Patent EP1572962.
JD093569 - Sequence 74593 from Patent EP1572962.
JD403337 - Sequence 384361 from Patent EP1572962.
JD440660 - Sequence 421684 from Patent EP1572962.
JD436500 - Sequence 417524 from Patent EP1572962.
JD154082 - Sequence 135106 from Patent EP1572962.
JD379175 - Sequence 360199 from Patent EP1572962.
JD283595 - Sequence 264619 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4QN22, NM_024841, NP_079117, PROTOR2, PRR5L_HUMAN, Q6MZQ0, Q96H46, Q9H7V4
UCSC ID: uc001mwp.3
RefSeq Accession: NM_024841
Protein: Q6MZQ0 (aka PRR5L_HUMAN)
CCDS: CCDS31463.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_024841.4
exon count: 10CDS single in 3' UTR: no RNA size: 3965
ORF size: 1107CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2212.50frame shift in genome: no % Coverage: 99.62
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.