ID:PRR5L_HUMAN DESCRIPTION: RecName: Full=Proline-rich protein 5-like; AltName: Full=Protein observed with Rictor-2; Short=Protor-2; FUNCTION: May be part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. SUBUNIT: May replace PRR5 in the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. SIMILARITY: Belongs to the PROTOR family. SEQUENCE CAUTION: Sequence=AAI25123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PRR5L CDC HuGE Published Literature: PRR5L Positive Disease Associations: Alcoholism
, Creatinine Related Studies:
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6MZQ0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001933 negative regulation of protein phosphorylation GO:0001934 positive regulation of protein phosphorylation GO:0009968 negative regulation of signal transduction GO:0010762 regulation of fibroblast migration GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0034599 cellular response to oxidative stress GO:0038203 TORC2 signaling GO:0061014 positive regulation of mRNA catabolic process GO:0090316 positive regulation of intracellular protein transport