Description: Homo sapiens ribonuclease, RNase A family, 3 (RNASE3), mRNA. RefSeq Summary (NM_002935): The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]. Transcript (Including UTRs) Position: hg19 chr14:21,359,562-21,360,507 Size: 946 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr14:21,359,846-21,360,328 Size: 483 Coding Exon Count: 1
ID:ECP_HUMAN DESCRIPTION: RecName: Full=Eosinophil cationic protein; Short=ECP; EC=3.1.27.-; AltName: Full=Ribonuclease 3; Short=RNase 3; Flags: Precursor; FUNCTION: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. SUBUNIT: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid- like aggregates at pH 3, but not at pH 5, nor 7. SUBCELLULAR LOCATION: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus. SIMILARITY: Belongs to the pancreatic ribonuclease family.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): RNASE3 CDC HuGE Published Literature: RNASE3 Positive Disease Associations: asthma Related Studies:
asthma Munthe-Kaas, M. C. et al. 2007, Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes, Allergy 2007 62(4) 429-36.
[PubMed 17362255]
The present study suggests that the A-G-G haplotype in the RNASE3 gene influences the development of asthma, in particular, an allergic form of asthma. Furthermore, as the -38CA SNP lies in close vicinity of known intron-regulatory sites, results of SNP analysis suggest that the detected association is possibly linked to a genetic transcriptional control of
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P12724
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
