Description: Homo sapiens ras responsive element binding protein 1 (RREB1), transcript variant 1, mRNA. RefSeq Summary (NM_001003699): The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. Transcript (Including UTRs) Position: hg19 chr6:7,108,086-7,252,213 Size: 144,128 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr6:7,182,145-7,249,201 Size: 67,057 Coding Exon Count: 10
Macular Degeneration Benjamin M Neale et al. Proceedings of the National Academy of Sciences of the United States of America 2010, Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)., Proceedings of the National Academy of Sciences of the United States of America.
[PubMed 20385826]
implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD.
Parkinson Disease Hon-Chung Fung et al. Lancet neurology 2006, Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data., Lancet neurology.
[PubMed 17052657]
We generated publicly available genotype data for Parkinsons disease patients and controls so that these data can be mined and augmented by other researchers to identify common genetic variability that results in minor and moderate risk for disease.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00096 - Zinc finger, C2H2 type PF12874 - Zinc-finger of C2H2 type PF13894 - C2H2-type zinc finger PF13909 - C2H2-type zinc-finger domain PF13912 - C2H2-type zinc finger
ModBase Predicted Comparative 3D Structure on Q92766-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
