Description: Homo sapiens solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1), transcript variant 1, mRNA. RefSeq Summary (NM_003051): The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr1:113,454,470-113,498,975 Size: 44,506 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr1:113,456,513-113,471,930 Size: 15,418 Coding Exon Count: 4
ID:MOT1_HUMAN DESCRIPTION: RecName: Full=Monocarboxylate transporter 1; Short=MCT 1; AltName: Full=Solute carrier family 16 member 1; FUNCTION: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. INTERACTION: P61966:AP1S1; NbExp=1; IntAct=EBI-1054708, EBI-516199; O15121:DEGS1; NbExp=1; IntAct=EBI-1054708, EBI-1052713; Q13530:SERINC3; NbExp=1; IntAct=EBI-1054708, EBI-1045571; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in normal and in cancer cells. DISEASE: Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT) [MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. DISEASE: Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7) [MIM:610021]; also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. SIMILARITY: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07690 - Major Facilitator Superfamily
SCOP Domains: 103473 - MFS general substrate transporter
ModBase Predicted Comparative 3D Structure on P53985
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL162079 - Homo sapiens mRNA; cDNA DKFZp762B2310 (from clone DKFZp762B2310). AK000641 - Homo sapiens cDNA FLJ20634 fis, clone KAT03557, highly similar to L31801 Homo sapiens monocarboxylate transporter 1. BC026317 - Homo sapiens solute carrier family 16, member 1 (monocarboxylic acid transporter 1), mRNA (cDNA clone MGC:26141 IMAGE:4811581), complete cds. AJ438942 - Homo sapiens mRNA for monocarboxylate transporter isoform 1 (SLC16A1 gene), 3'UTR. JD048514 - Sequence 29538 from Patent EP1572962. JD438699 - Sequence 419723 from Patent EP1572962. JD345424 - Sequence 326448 from Patent EP1572962. JD207153 - Sequence 188177 from Patent EP1572962. JD302386 - Sequence 283410 from Patent EP1572962. L31801 - Homo sapiens monocarboxylate transporter 1 (SLC16A1) mRNA, complete cds. JD098891 - Sequence 79915 from Patent EP1572962. JD294832 - Sequence 275856 from Patent EP1572962. JD182712 - Sequence 163736 from Patent EP1572962. JD271649 - Sequence 252673 from Patent EP1572962. JD289628 - Sequence 270652 from Patent EP1572962. AK296688 - Homo sapiens cDNA FLJ53381 complete cds, highly similar to Monocarboxylate transporter 1. AK303603 - Homo sapiens cDNA FLJ53399 complete cds, highly similar to Monocarboxylate transporter 1. JD385096 - Sequence 366120 from Patent EP1572962. EU831949 - Synthetic construct Homo sapiens clone HAIB:100066978; DKFZo008E0223 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) protein (SLC16A1) gene, encodes complete protein. EU832043 - Synthetic construct Homo sapiens clone HAIB:100067072; DKFZo004E0224 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) protein (SLC16A1) gene, encodes complete protein. AK312500 - Homo sapiens cDNA, FLJ92862, highly similar to Homo sapiens solute carrier family 16 (monocarboxylic acid transporters), member 1 (SLC16A1), mRNA. DQ895286 - Synthetic construct Homo sapiens clone IMAGE:100009746; FLH185576.01L; RZPDo839C09147D solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1) gene, encodes complete protein. EU176206 - Synthetic construct Homo sapiens clone IMAGE:100006457; FLH185583.01X; RZPDo839B05250D solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (SLC16A1) gene, encodes complete protein. AK094064 - Homo sapiens cDNA FLJ36745 fis, clone UTERU2014024, highly similar to MONOCARBOXYLATE TRANSPORTER 1. BC045664 - Homo sapiens solute carrier family 16, member 1 (monocarboxylic acid transporter 1), mRNA (cDNA clone MGC:44475 IMAGE:5298234), complete cds. AJ438943 - Homo sapiens mRNA for monocarboxylate transporter isoform 1 (SLC16A1 gene), 5'UTR. AF239919 - Homo sapiens colonic monocarboxylate transporter 1 (MCT1) gene, partial sequence. JD468249 - Sequence 449273 from Patent EP1572962. JD216618 - Sequence 197642 from Patent EP1572962. JD393347 - Sequence 374371 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P53985 (Reactome details) participates in the following event(s):
R-HSA-204392 Basigin binds MCT1, MCT3 and MCT4 R-HSA-433698 SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol R-HSA-373867 BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol R-HSA-373875 BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region R-HSA-210991 Basigin interactions R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-433692 Proton-coupled monocarboxylate transport R-HSA-109582 Hemostasis R-HSA-70268 Pyruvate metabolism R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425471 Bile salt and organic anion SLC transporters R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-425407 SLC-mediated transmembrane transport R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-382551 Transport of small molecules R-HSA-1430728 Metabolism
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