Description: Homo sapiens sprouty homolog 2 (Drosophila) (SPRY2), mRNA. RefSeq Summary (NM_005842): This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr13:80,910,112-80,915,086 Size: 4,975 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr13:80,910,893-80,911,840 Size: 948 Coding Exon Count: 1
ID:SPY2_HUMAN DESCRIPTION: RecName: Full=Protein sprouty homolog 2; Short=Spry-2; FUNCTION: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. SUBUNIT: Interacts with RAF1. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor). INDUCTION: By FGF signaling. DOMAIN: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. SIMILARITY: Belongs to the sprouty family. SIMILARITY: Contains 1 SPR (sprouty) domain.
Adiposity , Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile., Nature genetics.
[PubMed 21706003]
Creatinine Shih-Jen Hwang et al. BMC medical genetics 2007, A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study., BMC medical genetics.
[PubMed 17903292]
Kidney function traits and TSH are associated with SNPs on the Affymetrix GeneChip Human Mapping 100K SNP set. These data will serve as a valuable resource for replication as more SNPs associated with kidney function and endocrine traits are identified.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43597
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
