Description: Homo sapiens thymopoietin (TMPO), transcript variant 1, mRNA. RefSeq Summary (NM_003276): Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]. Transcript (Including UTRs) Position: hg19 chr12:98,909,351-98,929,412 Size: 20,062 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr12:98,909,646-98,928,120 Size: 18,475 Coding Exon Count: 4
ID:LAP2A_HUMAN DESCRIPTION: RecName: Full=Lamina-associated polypeptide 2, isoform alpha; AltName: Full=Thymopoietin isoform alpha; Short=TP alpha; AltName: Full=Thymopoietin-related peptide isoform alpha; Short=TPRP isoform alpha; Contains: RecName: Full=Thymopoietin; Short=TP; AltName: Full=Splenin; Contains: RecName: Full=Thymopentin; AltName: Full=TP5; FUNCTION: May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. FUNCTION: TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide. SUBUNIT: Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell- cycle stages. SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus. TISSUE SPECIFICITY: Expressed in many tissues. Most abundant in adult thymus and fetal liver. DOMAIN: The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1. DOMAIN: The C-terminal domain forms a four-stranded coiled coil (By similarity). PTM: Phosphorylated in a mitose-specific manner. DISEASE: Defects in TMPO are the cause of cardiomyopathy dilated type 1T (CMD1T) [MIM:613740]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. PHARMACEUTICAL: TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) and Mepentil (Recordati). Used in primary and secondary immune deficiencies, autoimmunity, infections and cancer. SIMILARITY: Belongs to the LEM family. SIMILARITY: Contains 1 LEM domain. SIMILARITY: Contains 1 LEM-like domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P42166
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
