Description: Homo sapiens vesicle-associated membrane protein 8 (VAMP8), mRNA. RefSeq Summary (NM_003761): This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]. Transcript (Including UTRs) Position: hg19 chr2:85,804,614-85,809,156 Size: 4,543 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr2:85,804,770-85,808,839 Size: 4,070 Coding Exon Count: 3
ID:VAMP8_HUMAN DESCRIPTION: RecName: Full=Vesicle-associated membrane protein 8; Short=VAMP-8; AltName: Full=Endobrevin; Short=EDB; FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes (By similarity). SUBUNIT: Found in a number of SNARE complexes with NAPA, SNAP23, SNAP25, STX1A, STX4, STX7, STX8 and VTI1B (By similarity). Interacts with STX8 (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein (Probable). TISSUE SPECIFICITY: Platelets. SIMILARITY: Belongs to the synaptobrevin family. SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain.
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): VAMP8 CDC HuGE Published Literature: VAMP8 Positive Disease Associations: myocardial infarct Related Studies:
myocardial infarct Shiffman, D. et al. 2006, Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction, Arterioscler Thromb Vasc Biol 2006.
[PubMed 16690874]
Variants in 2 genes were associated with early-onset MI: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. The identification of these variants could improve understanding of disease mechanisms and suggest novel drug targets.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BV40
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0006906 vesicle fusion GO:0006914 autophagy GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0016240 autophagosome docking GO:0043312 neutrophil degranulation GO:0046718 viral entry into host cell GO:0061024 membrane organization GO:0070254 mucus secretion GO:0097352 autophagosome maturation GO:1903076 regulation of protein localization to plasma membrane GO:1903531 negative regulation of secretion by cell GO:1903595 positive regulation of histamine secretion by mast cell GO:0043308 eosinophil degranulation
US Server
