Human Gene ABO (ENST00000611156.4) from GENCODE V38
Description: Homo sapiens ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase (ABO), mRNA. (from RefSeq NM_020469) RefSeq Summary (NM_020469): This gene encodes proteins related to the first discovered blood group system, ABO. Variation in the ABO gene (chromosome 9q34.2) is the basis of the ABO blood group, thus the presence of an allele determines the blood group in an individual. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Sep 2019]. Sequence Note: This RefSeq record represents the ABO*A1.01 allele. Gencode Transcript: ENST00000611156.4 Gencode Gene: ENSG00000175164.16 Transcript (Including UTRs) Position: hg38 chr9:133,255,176-133,275,214 Size: 20,039 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr9:133,255,666-133,275,189 Size: 19,524 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.