Human Gene PLA2G2A (ENST00000375111.7) from GENCODE V44
Description: Homo sapiens phospholipase A2 group IIA (PLA2G2A), transcript variant 3, mRNA. (from RefSeq NM_001161728) RefSeq Summary (NM_000300): The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000375111.7 Gencode Gene: ENSG00000188257.12 Transcript (Including UTRs) Position: hg38 chr1:19,975,438-19,980,416 Size: 4,979 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:19,975,701-19,978,773 Size: 3,073 Coding Exon Count: 4
ID:PA2GA_HUMAN DESCRIPTION: RecName: Full=Phospholipase A2, membrane associated; EC=3.1.1.4; AltName: Full=GIIC sPLA2; AltName: Full=Group IIA phospholipase A2; AltName: Full=Non-pancreatic secretory phospholipase A2; Short=NPS-PLA2; AltName: Full=Phosphatidylcholine 2-acylhydrolase 2A; Flags: Precursor; FUNCTION: Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. COFACTOR: Binds 1 calcium ion per subunit. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. MISCELLANEOUS: Group II phospholipase A2 is found in many cells and also extracellularly. The membrane-bound and secreted forms are identical and are encoded by a single gene. SIMILARITY: Belongs to the phospholipase A2 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/pla2g2a/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14555
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
