Human Gene EXO5 (ENST00000296380.9) from GENCODE V44
Description: Homo sapiens exonuclease 5 (EXO5), transcript variant 2, mRNA. (from RefSeq NM_022774) RefSeq Summary (NM_022774): The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]. Gencode Transcript: ENST00000296380.9 Gencode Gene: ENSG00000164002.12 Transcript (Including UTRs) Position: hg38 chr1:40,508,761-40,516,036 Size: 7,276 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr1:40,514,545-40,515,666 Size: 1,122 Coding Exon Count: 1
ID:EXO5_HUMAN DESCRIPTION: RecName: Full=Probable exonuclease V; Short=Exo V; EC=3.1.11.-; AltName: Full=Defects in morphology protein 1 homolog; FUNCTION: Probable single strand DNA specific 5' exonuclease mitochondrial DNA replication and recombination (By similarity). COFACTOR: Magnesium (By similarity). SIMILARITY: Belongs to the EXO5 family. SEQUENCE CAUTION: Sequence=CAI16298.1; Type=Erroneous gene model prediction; Sequence=CAI16299.1; Type=Erroneous gene model prediction; Sequence=CAI16300.1; Type=Erroneous gene model prediction; Sequence=CAI16301.1; Type=Erroneous gene model prediction; Sequence=CAI16302.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09810 - Exonuclease V - a 5' deoxyribonuclease
ModBase Predicted Comparative 3D Structure on Q9H790
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.