Human Gene FAF1 (ENST00000396153.7) from GENCODE V44
Description: Homo sapiens Fas associated factor 1 (FAF1), mRNA. (from RefSeq NM_007051) RefSeq Summary (NM_007051): Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000396153.7 Gencode Gene: ENSG00000185104.21 Transcript (Including UTRs) Position: hg38 chr1:50,437,028-50,960,267 Size: 523,240 Total Exon Count: 19 Strand: - Coding Region Position: hg38 chr1:50,441,440-50,959,811 Size: 518,372 Coding Exon Count: 19
ID:FAF1_HUMAN DESCRIPTION: RecName: Full=FAS-associated factor 1; Short=hFAF1; AltName: Full=UBX domain-containing protein 12; AltName: Full=UBX domain-containing protein 3A; FUNCTION: Potentiates but cannot initiate FAS-induced apoptosis. SUBUNIT: Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. SIMILARITY: Contains 1 UBA domain. SIMILARITY: Contains 1 UBX domain. SEQUENCE CAUTION: Sequence=AAD51876.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UNN5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0008219 cell death GO:0010942 positive regulation of cell death GO:0030155 regulation of cell adhesion GO:0031334 positive regulation of protein complex assembly GO:0042176 regulation of protein catabolic process GO:0043065 positive regulation of apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045740 positive regulation of DNA replication GO:0045859 regulation of protein kinase activity GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903364 positive regulation of cellular protein catabolic process
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