Human Gene MAN1A2 (ENST00000356554.7) from GENCODE V44
Description: Homo sapiens mannosidase alpha class 1A member 2 (MAN1A2), mRNA. (from RefSeq NM_006699) RefSeq Summary (NM_006699): Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000356554.7 Gencode Gene: ENSG00000198162.12 Transcript (Including UTRs) Position: hg38 chr1:117,367,449-117,528,872 Size: 161,424 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr1:117,368,184-117,522,957 Size: 154,774 Coding Exon Count: 13
ID:MA1A2_HUMAN DESCRIPTION: RecName: Full=Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; EC=3.2.1.113; AltName: Full=Mannosidase alpha class 1A member 2; AltName: Full=Processing alpha-1,2-mannosidase IB; Short=Alpha-1,2-mannosidase IB; FUNCTION: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). CATALYTIC ACTIVITY: Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). COFACTOR: Calcium. ENZYME REGULATION: Inhibited by both 1-deoxymannojirimycin and kifunensine. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Highest levels of expression in placenta and testis. SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01532 - Glycosyl hydrolase family 47
ModBase Predicted Comparative 3D Structure on O60476
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00510 - N-Glycan biosynthesis hsa01100 - Metabolic pathways
BioCyc Knowledge Library PWY-7919 - protein N-glycosylation processing phase (mammalian)
BioCarta from NCI Cancer Genome Anatomy Project h_aMANpathway - Steps in the Glycosylation of Mammalian N-linked Oligosaccarides h_eradPathway - ER¿associated degradation (ERAD) Pathway
Reactome (by CSHL, EBI, and GO)
Protein O60476 (Reactome details) participates in the following event(s):
R-HSA-964737 Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2 R-HSA-964825 Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2 R-HSA-964830 Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2 R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering R-HSA-6811438 Intra-Golgi traffic R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins