Human Gene GATAD2B (ENST00000368655.5) from GENCODE V44
Description: Homo sapiens GATA zinc finger domain containing 2B (GATAD2B), mRNA. (from RefSeq NM_020699) RefSeq Summary (NM_020699): This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000368655.5 Gencode Gene: ENSG00000143614.11 Transcript (Including UTRs) Position: hg38 chr1:153,804,725-153,922,972 Size: 118,248 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr1:153,810,177-153,828,347 Size: 18,171 Coding Exon Count: 10
ID:P66B_HUMAN DESCRIPTION: RecName: Full=Transcriptional repressor p66-beta; AltName: Full=GATA zinc finger domain-containing protein 2B; AltName: Full=p66/p68; FUNCTION: Has transcriptional repressor activity. Targets MBD3 to discrete loci in the nucleus. SUBUNIT: Binds MBD2 and MBD3. Binds the MeCP1 complex. SUBCELLULAR LOCATION: Nucleus. Note=Nuclear, in discrete foci. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: CR1 is required for interaction with MBD3 and transcription repression. DOMAIN: CR2 is required for localization to discrete loci in the nucleus. SIMILARITY: Contains 1 GATA-type zinc finger.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WXI9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0031492 nucleosomal DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0043044 ATP-dependent chromatin remodeling
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