Human Gene SSR2 (ENST00000295702.9) from GENCODE V44
Description: Homo sapiens signal sequence receptor subunit 2 (SSR2), mRNA. (from RefSeq NM_003145) RefSeq Summary (NM_003145): The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000295702.9 Gencode Gene: ENSG00000163479.14 Transcript (Including UTRs) Position: hg38 chr1:156,009,048-156,020,951 Size: 11,904 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr1:156,009,540-156,020,167 Size: 10,628 Coding Exon Count: 5
ID:SSRB_HUMAN DESCRIPTION: RecName: Full=Translocon-associated protein subunit beta; Short=TRAP-beta; AltName: Full=Signal sequence receptor subunit beta; Short=SSR-beta; Flags: Precursor; FUNCTION: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. SUBUNIT: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the TRAP-beta family. SEQUENCE CAUTION: Sequence=CAH72631.1; Type=Erroneous gene model prediction; Sequence=CAH72632.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05753 - Translocon-associated protein beta (TRAPB)
ModBase Predicted Comparative 3D Structure on P43308
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK222600 - Homo sapiens mRNA for signal sequence receptor, beta precursor variant, clone: CAS09563. BC000341 - Homo sapiens signal sequence receptor, beta (translocon-associated protein beta), mRNA (cDNA clone MGC:8566 IMAGE:2822983), complete cds. AK092473 - Homo sapiens cDNA FLJ35154 fis, clone PLACE6010848, moderately similar to TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR. D37991 - Homo sapiens SSR2 mRNA for beta-signal sequence receptor, complete cds. BC010085 - Homo sapiens signal sequence receptor, beta (translocon-associated protein beta), mRNA (cDNA clone IMAGE:2905393). AK300678 - Homo sapiens cDNA FLJ56303 complete cds, highly similar to Translocon-associated protein subunit beta precursor. X74104 - H.sapiens mRNA for TRAP beta subunit. AY251536 - Homo sapiens HSD25 mRNA, complete cds. JD560216 - Sequence 541240 from Patent EP1572962. JD355854 - Sequence 336878 from Patent EP1572962. JD102609 - Sequence 83633 from Patent EP1572962. JD132560 - Sequence 113584 from Patent EP1572962. JD172300 - Sequence 153324 from Patent EP1572962. JD532424 - Sequence 513448 from Patent EP1572962. JD167521 - Sequence 148545 from Patent EP1572962. JD336138 - Sequence 317162 from Patent EP1572962. JD255155 - Sequence 236179 from Patent EP1572962. JD255477 - Sequence 236501 from Patent EP1572962. JD226199 - Sequence 207223 from Patent EP1572962. JD528288 - Sequence 509312 from Patent EP1572962. JD213624 - Sequence 194648 from Patent EP1572962. JD428526 - Sequence 409550 from Patent EP1572962. AK313821 - Homo sapiens cDNA, FLJ94442, Homo sapiens signal sequence receptor, beta (translocon-associatedprotein beta) (SSR2), mRNA. KJ892204 - Synthetic construct Homo sapiens clone ccsbBroadEn_01598 SSR2 gene, encodes complete protein. CR456973 - Homo sapiens full open reading frame cDNA clone RZPDo834C035D for gene SSR2, signal sequence receptor, beta (translocon-associated protein beta); complete cds, incl. stopcodon. BX649192 - Homo sapiens mRNA; cDNA DKFZp686F19123 (from clone DKFZp686F19123). DL491912 - Novel nucleic acids. DL490475 - Novel nucleic acids. JD282859 - Sequence 263883 from Patent EP1572962. JD479179 - Sequence 460203 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P43308 (Reactome details) participates in the following event(s):
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum R-HSA-1799329 Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
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