ID:UBQL4_HUMAN DESCRIPTION: RecName: Full=Ubiquilin-4; AltName: Full=Ataxin-1 interacting ubiquitin-like protein; Short=A1Up; AltName: Full=Ataxin-1 ubiquitin-like-interacting protein A1U; AltName: Full=Connexin43-interacting protein of 75 kDa; Short=CIP75; FUNCTION: Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation. SUBUNIT: Binds signal sequences of proteins that are targeted to the endoplasmic reticulum. Interacts (via UBA domain) with GJA1 (not ubiquitinated) and with ubiquitin; both compete for the same binding site (By similarity). Homodimer. Interacts (via UBA domain) with ubiquitin and with polyubiquitin chains. Interacts (via ubiquitin-like domain) with PSMD4, a regulatory subunit of the 26S proteasome. Interacts with ATXN1/SCA1. Interaction with ATXN1 inhibits polyubiquitination of UBQLN4 and interferes with PSMD4 binding. INTERACTION: P54253:ATXN1; NbExp=6; IntAct=EBI-711226, EBI-930964; P26885:FKBP2; NbExp=2; IntAct=EBI-711226, EBI-719873; P55198:MLLT6; NbExp=2; IntAct=EBI-711226, EBI-740216; Q9NR12:PDLIM7; NbExp=2; IntAct=EBI-711226, EBI-350517; Q9Y5P3:RAI2; NbExp=3; IntAct=EBI-711226, EBI-746228; Q13049:TRIM32; NbExp=3; IntAct=EBI-711226, EBI-742790; O95201:ZNF205; NbExp=2; IntAct=EBI-711226, EBI-747343; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum (Probable). Cytoplasm, perinuclear region (By similarity). Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. May associate with the endoplasmic reticulum. TISSUE SPECIFICITY: Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: Ubiquitinated; this does not lead to proteasomal degradation. May undergo both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. SIMILARITY: Contains 1 UBA domain. SIMILARITY: Contains 1 ubiquitin-like domain. SEQUENCE CAUTION: Sequence=AAF19084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH06410.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00627 - UBA/TS-N domain PF00240 - Ubiquitin family
ModBase Predicted Comparative 3D Structure on Q9NRR5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006914 autophagy GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:1901097 negative regulation of autophagosome maturation
US Server
