Human Gene OPN3 (ENST00000366554.3) from GENCODE V44
Description: Homo sapiens opsin 3 (OPN3), transcript variant 1, mRNA. (from RefSeq NM_014322) RefSeq Summary (NM_014322): Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000366554.3 Gencode Gene: ENSG00000054277.14 Transcript (Including UTRs) Position: hg38 chr1:241,593,124-241,640,369 Size: 47,246 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr1:241,594,428-241,640,254 Size: 45,827 Coding Exon Count: 4
ID:OPN3_HUMAN DESCRIPTION: RecName: Full=Opsin-3; AltName: Full=Encephalopsin; AltName: Full=Panopsin; FUNCTION: May play a role in encephalic photoreception. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strongly expressed in brain. Highly expressed in the preoptic area and paraventricular nucleus of the hypothalamus. Shows highly patterned expression in other regions of the brain, being enriched in selected regions of the cerebral cortex, cerebellar Purkinje cells, a subset of striatal neurons, selected thalamic nuclei, and a subset of interneurons in the ventral horn of the spinal cord. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H1Y3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007602 phototransduction GO:0009583 detection of light stimulus GO:0009584 detection of visible light GO:0018298 protein-chromophore linkage GO:0042752 regulation of circadian rhythm GO:0050896 response to stimulus
Cellular Component: GO:0001750 photoreceptor outer segment GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
AF303588 - Homo sapiens panopsin (OPN3) mRNA, complete cds. BC073872 - Homo sapiens opsin 3, mRNA (cDNA clone IMAGE:4452104), complete cds. BC026242 - Homo sapiens mRNA similar to opsin 3 (encephalopsin, panopsin) (cDNA clone IMAGE:4669517). AF140242 - Homo sapiens encephalopsin mRNA, complete cds. BC062622 - Homo sapiens opsin 3, mRNA (cDNA clone IMAGE:5200803), complete cds. BC036773 - Homo sapiens opsin 3, mRNA (cDNA clone MGC:46103 IMAGE:5723543), complete cds. BC051900 - Homo sapiens opsin 3, mRNA (cDNA clone IMAGE:5181517). JD173402 - Sequence 154426 from Patent EP1572962. JD108507 - Sequence 89531 from Patent EP1572962. JD540179 - Sequence 521203 from Patent EP1572962. JD546704 - Sequence 527728 from Patent EP1572962. JD042203 - Sequence 23227 from Patent EP1572962. JD296329 - Sequence 277353 from Patent EP1572962. JD381876 - Sequence 362900 from Patent EP1572962. JD315859 - Sequence 296883 from Patent EP1572962. AK310307 - Homo sapiens cDNA, FLJ17349. KJ893412 - Synthetic construct Homo sapiens clone ccsbBroadEn_02806 OPN3 gene, encodes complete protein. JD450233 - Sequence 431257 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H1Y3 (Reactome details) participates in the following event(s):