ID:TFB2M_HUMAN DESCRIPTION: RecName: Full=Dimethyladenosine transferase 2, mitochondrial; EC=2.1.1.-; AltName: Full=Hepatitis C virus NS5A-transactivated protein 5; Short=HCV NS5A-transactivated protein 5; AltName: Full=Mitochondrial 12S rRNA dimethylase 2; AltName: Full=Mitochondrial transcription factor B2; Short=h-mtTFB; Short=h-mtTFB2; Short=hTFB2M; Short=mtTFB2; AltName: Full=S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; Flags: Precursor; FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. SUBUNIT: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM. SUBCELLULAR LOCATION: Mitochondrion. TISSUE SPECIFICITY: Ubiquitously expressed. INDUCTION: By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators. SIMILARITY: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily. SEQUENCE CAUTION: Sequence=BAB15441.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H5Q4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
