Human Gene GJD4 (ENST00000321660.2) from GENCODE V44
Description: Homo sapiens gap junction protein delta 4 (GJD4), mRNA. (from RefSeq NM_153368) RefSeq Summary (NM_153368): Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]. Gencode Transcript: ENST00000321660.2 Gencode Gene: ENSG00000177291.4 Transcript (Including UTRs) Position: hg38 chr10:35,605,341-35,608,935 Size: 3,595 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr10:35,605,568-35,608,626 Size: 3,059 Coding Exon Count: 2
ID:CXD4_HUMAN DESCRIPTION: RecName: Full=Gap junction delta-4 protein; AltName: Full=Connexin-40.1; Short=Cx40.1; FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity). SUBUNIT: A connexon is composed of a hexamer of connexins (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, gap junction (By similarity). TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, liver, placenta, and heart. SIMILARITY: Belongs to the connexin family. Delta-type subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96KN9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
