Human Gene PPP1R3C (ENST00000238994.6) from GENCODE V44
Description: Homo sapiens protein phosphatase 1 regulatory subunit 3C (PPP1R3C), mRNA. (from RefSeq NM_005398) RefSeq Summary (NM_005398): This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]. Gencode Transcript: ENST00000238994.6 Gencode Gene: ENSG00000119938.9 Transcript (Including UTRs) Position: hg38 chr10:91,628,442-91,633,071 Size: 4,630 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr10:91,629,927-91,632,969 Size: 3,043 Coding Exon Count: 2
ID:PPR3C_HUMAN DESCRIPTION: RecName: Full=Protein phosphatase 1 regulatory subunit 3C; AltName: Full=Protein phosphatase 1 regulatory subunit 5; Short=PP1 subunit R5; AltName: Full=Protein targeting to glycogen; Short=PTG; FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. SUBUNIT: Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin. INTERACTION: O95278:EPM2A; NbExp=5; IntAct=EBI-2506727, EBI-2506661; DOMAIN: The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C- terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase (By similarity). PTM: Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner. SIMILARITY: Contains 1 CBM21 (carbohydrate binding type-21) domain. SEQUENCE CAUTION: Sequence=AAD33215.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UQK1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004722 protein serine/threonine phosphatase activity GO:0005515 protein binding GO:0019888 protein phosphatase regulator activity GO:0019903 protein phosphatase binding
Biological Process: GO:0005975 carbohydrate metabolic process GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0006470 protein dephosphorylation GO:0043666 regulation of phosphoprotein phosphatase activity
US Server
