Human Gene TRIM34 (ENST00000514226.5) from GENCODE V44
Description: Homo sapiens tripartite motif containing 34 (TRIM34), transcript variant 4, mRNA. (from RefSeq NM_001003827) RefSeq Summary (NM_001003827): The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]. Gencode Transcript: ENST00000514226.5 Gencode Gene: ENSG00000258659.7 Transcript (Including UTRs) Position: hg38 chr11:5,619,764-5,644,398 Size: 24,635 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr11:5,632,332-5,643,709 Size: 11,378 Coding Exon Count: 7
ID:TRI34_HUMAN DESCRIPTION: RecName: Full=Tripartite motif-containing protein 34; AltName: Full=Interferon-responsive finger protein 1; AltName: Full=RING finger protein 21; TISSUE SPECIFICITY: Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. INDUCTION: Isoform 1 is up-regulated by interferons. SIMILARITY: Belongs to the TRIM/RBCC family. SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=AAG53517.1; Type=Erroneous initiation; Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=The biological existence and relevance of this transcript that contains the product of both TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYJ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
