Human Gene ELP4 (ENST00000640961.2) from GENCODE V44
Description: Homo sapiens elongator acetyltransferase complex subunit 4 (ELP4), transcript variant 1, mRNA. (from RefSeq NM_019040) RefSeq Summary (NM_019040): This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. Gencode Transcript: ENST00000640961.2 Gencode Gene: ENSG00000109911.19 Transcript (Including UTRs) Position: hg38 chr11:31,509,767-31,790,324 Size: 280,558 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr11:31,509,785-31,783,524 Size: 273,740 Coding Exon Count: 10
ID:ELP4_HUMAN DESCRIPTION: RecName: Full=Elongator complex protein 4; Short=hELP4; AltName: Full=PAX6 neighbor gene protein; FUNCTION: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. SUBUNIT: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the ELP4 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96EB1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
