Human Gene UBE2L6 (ENST00000287156.9) from GENCODE V44
Description: Homo sapiens ubiquitin conjugating enzyme E2 L6 (UBE2L6), transcript variant 1, mRNA. (from RefSeq NM_004223) RefSeq Summary (NM_004223): The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000287156.9 Gencode Gene: ENSG00000156587.16 Transcript (Including UTRs) Position: hg38 chr11:57,551,662-57,567,672 Size: 16,011 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr11:57,552,358-57,567,611 Size: 15,254 Coding Exon Count: 4
ID:UB2L6_HUMAN DESCRIPTION: RecName: Full=Ubiquitin/ISG15-conjugating enzyme E2 L6; EC=6.3.2.19; AltName: Full=Retinoic acid-induced gene B protein; Short=RIG-B; AltName: Full=UbcH8; AltName: Full=Ubiquitin carrier protein L6; AltName: Full=Ubiquitin-protein ligase L6; FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). INTERACTION: Q6ZMZ0:RNF19B; NbExp=3; IntAct=EBI-2129974, EBI-2466594; Q8CJB9:Rnf40 (xeno); NbExp=2; IntAct=EBI-2129974, EBI-6110162; TISSUE SPECIFICITY: Present in natural killer cells (at protein level). INDUCTION: By IFNB1/IFN-beta. PTM: ISGylated. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=CAB64566.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14933
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006464 cellular protein modification process GO:0016567 protein ubiquitination GO:0019941 modification-dependent protein catabolic process GO:0019985 translesion synthesis GO:0032020 ISG15-protein conjugation GO:0032480 negative regulation of type I interferon production GO:0044267 cellular protein metabolic process
AK093462 - Homo sapiens cDNA FLJ36143 fis, clone TESTI2025013, highly similar to UBIQUITIN-CONJUGATING ENZYME E2-18 KDA UBCH8 (EC 6.3.2.19). AK129621 - Homo sapiens cDNA FLJ26110 fis, clone SPL05701, highly similar to Ubiquitin-conjugating enzyme E2-18 kDa UBCH8 (EC 6.3.2.19). AF061736 - Homo sapiens ubiquitin-conjugating enzyme RIG-B mRNA, complete cds. BC032491 - Homo sapiens ubiquitin-conjugating enzyme E2L 6, mRNA (cDNA clone MGC:40331 IMAGE:5246109), complete cds. AK226165 - Homo sapiens mRNA for ubiquitin-conjugating enzyme E2L 6 isoform 1 variant, clone: bm01123. JD357689 - Sequence 338713 from Patent EP1572962. JD385415 - Sequence 366439 from Patent EP1572962. JD491767 - Sequence 472791 from Patent EP1572962. JD296662 - Sequence 277686 from Patent EP1572962. JD177289 - Sequence 158313 from Patent EP1572962. JD445732 - Sequence 426756 from Patent EP1572962. JD073506 - Sequence 54530 from Patent EP1572962. JD078520 - Sequence 59544 from Patent EP1572962. JD331250 - Sequence 312274 from Patent EP1572962. JD284865 - Sequence 265889 from Patent EP1572962. JD045407 - Sequence 26431 from Patent EP1572962. JD229400 - Sequence 210424 from Patent EP1572962. JD099867 - Sequence 80891 from Patent EP1572962. JD374576 - Sequence 355600 from Patent EP1572962. JD051156 - Sequence 32180 from Patent EP1572962. JD324670 - Sequence 305694 from Patent EP1572962. JD142312 - Sequence 123336 from Patent EP1572962. AF031141 - Homo sapiens ubiquitin conjugating enzyme (UbcH8) mRNA, complete cds. CR457126 - Homo sapiens full open reading frame cDNA clone RZPDo834F107D for gene UBE2L6, ubiquitin-conjugating enzyme E2L 6; complete cds, incl. stopcodon. AK315755 - Homo sapiens cDNA, FLJ96866, Homo sapiens ubiquitin-conjugating enzyme E2L 6 (UBE2L6), mRNA. DQ891291 - Synthetic construct clone IMAGE:100003921; FLH170793.01X; RZPDo839B08100D ubiquitin-conjugating enzyme E2L 6 (UBE2L6) gene, encodes complete protein. KJ892727 - Synthetic construct Homo sapiens clone ccsbBroadEn_02121 UBE2L6 gene, encodes complete protein. DQ894475 - Synthetic construct Homo sapiens clone IMAGE:100008935; FLH170789.01L; RZPDo839B0899D ubiquitin-conjugating enzyme E2L 6 (UBE2L6) gene, encodes complete protein. CU689396 - Synthetic construct Homo sapiens gateway clone IMAGE:100016709 5' read UBE2L6 mRNA.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04120 - Ubiquitin mediated proteolysis hsa05012 - Parkinson's disease
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein O14933 (Reactome details) participates in the following event(s):
R-HSA-1169404 Transfer of ISG15 from E1 to E2 (UBCH8) R-HSA-1169394 ISGylation of IRF3 R-HSA-1169395 ISGylation of viral protein NS1 R-HSA-1169398 ISGylation of host protein filamin B R-HSA-1169402 ISGylation of E2 conjugating enzymes R-HSA-1169405 ISGylation of protein phosphatase 1 beta (PP2CB) R-HSA-1169406 ISGylation of host proteins R-HSA-1169403 Interaction of E3 ligase with ISG15:E2 complex R-HSA-5660753 SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-5653756 TRIM25 binds monoUb:164-PCNA R-HSA-5653754 UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA R-HSA-1678843 ISGylation of protein translation regulator 4EHP R-HSA-5658496 SIAH1:UBE2L6:Ubiquitin binds SNCA R-HSA-936563 ISGylation of DDX58 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP R-HSA-1169408 ISG15 antiviral mechanism R-HSA-977225 Amyloid fiber formation R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-392499 Metabolism of proteins R-HSA-5656169 Termination of translesion DNA synthesis R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-913531 Interferon Signaling R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-168249 Innate Immune System R-HSA-1280218 Adaptive Immune System R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-73893 DNA Damage Bypass R-HSA-168256 Immune System R-HSA-73894 DNA Repair
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