Human Gene ESRRA (ENST00000000442.11) from GENCODE V44
Description: Homo sapiens estrogen related receptor alpha (ESRRA), transcript variant 1, mRNA. (from RefSeq NM_004451) RefSeq Summary (NM_004451): The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019]. Gencode Transcript: ENST00000000442.11 Gencode Gene: ENSG00000173153.17 Transcript (Including UTRs) Position: hg38 chr11:64,305,524-64,316,743 Size: 11,220 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr11:64,307,180-64,315,966 Size: 8,787 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00104 - Ligand-binding domain of nuclear hormone receptor PF00105 - Zinc finger, C4 type (two domains)
ModBase Predicted Comparative 3D Structure on Q569H8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0005496 steroid binding GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0030278 regulation of ossification GO:0032355 response to estradiol GO:0042127 regulation of cell proliferation GO:0043401 steroid hormone mediated signaling pathway GO:0045667 regulation of osteoblast differentiation GO:0045670 regulation of osteoclast differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051216 cartilage development GO:1900078 positive regulation of cellular response to insulin stimulus
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